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. 2020 Aug 30;21(17):6280. doi: 10.3390/ijms21176280

Figure 9.

Figure 9

Schematic representation of the synthesis of cyclic aminopeptidase N (APN)-targeting peptide (cNGR)-modified functionalized graphene oxide (GO) nanosheets and preparation of drug delivery system GP–cNGR/polyvinylpyrrolidone (PVP)/Combretastatin A4 (CA4) [165]. Top: scheme (a); bottom: scheme (b). (Reprinted with permission from Ding et al. ‘A tumor-targeting drug delivery system based on cyclic NGR-modified, combretastatin A4-loaded, functionalized graphene oxide nanosheets’. RSC Adv. 2016, 6, 68134–68140. Copyright (2020) Royal Society of Chemistry).