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Particle preparation using oxamide cleavable groups and enzyme-triggered cleavage of amide bonds causing degradation of the silica-based nanoparticles. TEM images of the bridged silsesquioxane (BS) composite nanomaterials in phosphate buffer solution, PBS (A) and in trypsin-PBS buffer (B) after 24 h of enzymatic degradation. Adapted from [18] (https://doi.org/10.1039/C5NR03065J), with permission from The Royal Society of Chemistry.
