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. 2020 Sep 21;26(35):5223–5247. doi: 10.3748/wjg.v26.i35.5223

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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The molecular landscape underlying stress granules formation in colorectal cancer. Stress granules (SGs) assembly in colorectal cancer cells is associated with several alterations in the expression of proteins involved in SG nucleation or clearance. The stress-related conditions within the tumor microenvironment and various antitumor agents can further promote SGs assembly. Several SG-associated proteins (RNA-binding proteins or others) contribute to various cancer-related processes such as cell cycle progression, apoptosis inhibition, angiogenesis, and chemoresistance. Illustrations were retrieved from Servier Medical art (https://smart.servier.com/). SG: Stress granules.