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. 2020 Aug 27;13(17):3795. doi: 10.3390/ma13173795

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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HCFA-MSNs. (i) A schematic illustration of hypoxia-activatable and cytoplasmic protein-powered fluorescence cascade amplifying (HCFA) MSNs. The HCFA-MSNs are composed of the β-cyclodextrin polymer (β-CDP) gatekeeper, loaded with both squarylium (SQ) dyes and black hole quencher 2 (BHQ2). (ii) In vivo fluorescence images of nude mice after the injection of a commercial small molecular fluorescent probe, the HCFA-MSNs, the control group or convalescent group of the HCFA-MSNs (from right to left), respectively. The most intense fluorescent signal can be observed the HCFA-MSNs. (iii) TEM image of the as-synthesised MSNs. Adapted with permission from Ref. [124]. Copyright (2020) American Chemical Society.