Figure 12.

(A) Schematic illustration of DOX-loaded zinc gallogermanate (ZGGO)@mSiO₂@GFLG-SS-pHLIP composed of persistent luminescent nanoparticle (PLNP)/MSN core/shell structure, glutathione/cathepsin B dual-responsive polypeptide coating (pHLIP-SS-GFLG) and anticancer drug (DOX). This nanosystem is designed to achieve drug delivery under glutathione or/and cathepsin B conditions. (B) TEM image of ZGGO@mSiO₂. (C) Confocal laser scanning microscopy images of stained A549 cells, ZGGO@mSiO₂@GFLG-SS-pHLIP, and merged (from left to right). (D) The drug release profile of DOX-loaded ZGGO@mSiO₂@GFLG-SS-pHLIP in PBS buffer solution with or without stimulus (glutathione and cathepsin B). Adapted with permission from reference [147]. Copyright (2020) American Chemical Society.