Table 5.

Comparison of this study with previous published works on 2D-QSAR model for BACE1.

Source	Model	Training Set			Validation Set
		N	R2	Q2	n	R2PRED
This study	PLS	150	0.80	0.77	65	0.81
Ambure et al. 2016 [79]	PLS	52	0.83	0.76	22	0.81
Ambure et al. 2016 [79]	MLR	51	0.83	0.76	22	0.80
Hossain et al. 2013 [80]	CoMFA	71	1.00	0.77	35	0.77
Hossain et al. 2013 [80]	CoMSIA	71	1.00	0.73	35	0.71
Hossain et al. 2013 [80]	PLS	71	0.94	0.79	35	0.71
Roy et al. 2018 [77]	MLR	51	0.76–0.83	0.71–0.76	23	0.75–0.91

PLS: Partial least squares; MLR: Multiple linear regression; CoMFA: Comparative molecular field analysis; CoMSIA: Comparative similarity indices analysis; LHM: Linear heuristic method; N: number of compounds.