Figure 2.

Cytotoxic effects of Pro9-3 and its analogs: (A) dose–response curves for sheep red blood cell (sRBC) hemolysis induced by peptides and (B) dose-dependent (0–50 μM) cytotoxicity of the peptides against mouse macrophage RAW264.7 cells for 24 h. Melittin was used as a control. The values are expressed as the mean ± SEM of three independent experiments and are statistically significant at * p < 0.05, ** p < 0.01, and *** p < 0.001; ns, not significant (by one-way ANOVA, Tukey’s post hoc test).