Figure 13.

Pro10-1D treatment ameliorates lung microanatomical changes in E. coli K1-infected mice. Representative hematoxylin and eosin staining of lung tissue of (A) the control shows normal lung anatomy, while that of (B) E. coli K1-infected mice (6 × 10⁶ CFU/mice, Intra-peritoneal injection (I.P.)) displays severe lung damage associated with neutrophil infiltration. (C) No sign of lung damage can be observed in the Pro10-1D-treated control mice (1 mg/Kg, I.P.), while (D) Pro10-1D pretreatment distinctly ameliorated the aberrant changes induced by E. coli K1 infection (×20 magnification, scale bar, 100 μm).