Table 2.

Activities of Pro9-3 and its analogs against microorganisms.

Microorganisms		Minimal Inhibitory Concentration (MIC100) in μM
	Pro9-3	Pro9-3D	Pro10-1	Pro10-1D	Melittin
Standard gram-negative bacteria	16	8	16	8	8
E. Coli	16	4	16	4	8
E. coli K1
A. baumannii	16	4	8	2	4
MDR Gram-negative bacteria
MDREC 1229	16	8	8	4	16
MDREC 1238	32	4	32	4	32
MDRAB 12010	16	8	8	4	8
MDRAB 12220	16	8	16	8	8
a GM	18.29	6.29	14.86	4.86	12.0
b HC10	200	200	200	200	0.8
c Relative selective index	10.94	31.82	13.46	41.18	0.07

^a The geometric means (GMs) are the mean minimum inhibitory concentration (MIC) values of all bacterial strains. The average MIC was calculated from three experimental measurements. ^b HC₁₀ is the degree of peptide concentration inducing 10% hemolysis of heparinized sheep red blood cells in vitro. When no detectable hemolysis was observed at 100 μM, 200 μM was used to calculate the relative selective index. ^c Relative selective index was calculated using GM of the MIC (μM)/HC₁₀. The larger values indicate greater cell selectivity.