Figure 2.

Effect of increasing concentrations of prodigiosin or undecylprodigiosin on cell migration by the scratch wound assay. HUVEC monolayers were incubated for 8 h with 10 ng/mL vascular endothelial growth factor A (VEGF-A), while SMC monolayers were incubated for 24 h with 30 ng/mL human platelet-derived growth factor-BB (PDGF-BB). Quantification of HUVEC (A) or SMC (B) migration relative to control group. Data are expressed as mean ± SD. ^c, p < 0,001; ^d, p < 0.0001; ANOVA with Dunnett’s post hoc test. (C) Representative pictures show cell migration after 24 h of treatment. Dashed lines flank non-invaded area. The results were confirmed in five independent experiments (5 replicates per experiment).