Table 1.
Alterations in selected genes expression in human biopsies derived from patients with Barrett’s metaplasia as compared with normal squamous epithelium, based on analysis of the database no GSE13083 [8], GSE34619 [9] and GSE1420 [24]. Asterisk (*) indicates statistically significant difference with p < 0.05 in parallel with logFC values lower than −2 or higher than 2.
| Database No GSE13083 (n = 7): Barrett’s Metaplasia (7 Samples) vs. Normal Squamous Epithelium (7 Samples) | Database No GSE34619 (n = 18): Barrett’s Metaplasia (n =10) vs. Normal Squamous Epithelium (n = 8) | Database No GSE1420 (n = 16): Barrett’s Metaplasia (n = 8) vs. Normal Squamous Epithelium (n = 8) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | Predicted Type of Epithelium | Gene ID | logFC | p Value | Gene ID | logFC | p Value | Gene ID | logFC | p Value |
| KRT1 | squamous (esophageal) | 205900_at | −7.49126 | 1.11e−05 * | 7963491 | −3.3024845 | 1.10e−03 * | 205900_at | −2.217323 | 0.277797 |
| KRT4 | squamous (esophageal) | 213240_s_at | −4.6401743 | 5.80e−02 | 7963534 | −5.428193 | 2.16e−05 * | 214399_s_at | 0.9627934 | 0.291337 |
| KRT5 | squamous (esophageal) | 201820_at | −6.9473657 | 1.02e−02 * | 7963427 | −5.19733 | 1.27e−05 * | 201820_at | 0.2659335 | 0.939807 |
| KRT6A, 6B, 6C | squamous (esophageal) | 214580_x_at | −5.0172743 | 3.66e−02 * | 7963410 | −4.5273685 | 7.31e−05 * | 214580_x_at | 0.3930203 | 0.885997 |
| KRT10 | squamous (esophageal) | 207023_x_at | −1.9265443 | 4.80e−03 * | 8015104 | −1.9039765 | 1.43e−02 * | 207023_x_at | 0.0731168 | 0.925068 |
| KRT13 | squamous (esophageal) | 207935_s_at | −5.3344986 | 4.04e−02 * | 8015323 | −5.5419725 | 5.55e−05 * | 207935_s_at | 0.4701058 | 0.861817 |
| KRT14 | squamous (esophageal) | 209351_at | −4.0982471 | 1.17e−01 | 8015366 | −2.2296553 | 1.88e−03 * | 209351_at | 1.928972 | 0.499067 |
| KRT15 | squamous (esophageal) | 204734_at | −6.05938 | 2.09e−03 * | 8015337 | −4.686177 | 2.79e−10 * | 204734_at | −0.327417 | 0.941066 |
| KRT16 | squamous (esophageal) | 209800_at | −5.0731586 | 5.63e−03 * | 8015376 | −3.5205307 | 2.61e−05 * | 209800_at | 1.16582 | 0.682918 |
| KRT17 | squamous (esophageal) | 212236_x_at | −2.6745814 | 8.21e−02 | 8005449 | −1.7824035 | 1.42e−03 * | 205157_s_at | 2.6061311 | 0.297826 |
| KRT23 | squamous (esophageal) | 218963_s_at | −2.0889186 | 3.74e−02 * | 8015133 | −1.2800192 | 7.70e−02 | 218963_s_at | 0.0060589 | 0.997257 |
| KRT24 | squamous (esophageal) | 220267_at | −4.4806771 | 2.26e−03 * | 8015060 | −2.905637 | 7.73e−05 * | 220267_at | −0.676433 | 0.81305 |
| KRT7 | columnar (intestinal) | 209016_s_at | 2.2155471 | 4.07e−02 * | 7955613 | 1.9065172 | 5.46e−06 * | 209016_s_at | 1.6998427 | 0.204673 |
| KRT8 | columnar (intestinal) | 209008_x_at | 6.4172871 | 2.18e−09 * | 7963567 | 4.0091988 | 3.50e−11 * | 209008_x_at | 2.6806701 | 0.027973 * |
| KRT18 | columnar (intestinal) | 201596_x_at | 3.4490243 | 5.03e−06 * | 8154725 | 2.024285 | 2.16e−06 * | 201596_x_at | 1.9282774 | 0.082523 |
| KRT19 | columnar (intestinal) | 201650_at | 1.7536714 | 1.01e−03 * | 8015349 | 0.759105 | 3.08e−02 | 201650_at | 1.2141959 | 0.658343 |
| KRT20 | columnar (intestinal) | 213953_at | 8.5259443 | 3.44e−09 * | 8015124 | 4.374532 | 2.00e−04 * | 213953_at | 4.8072071 | 0.037302 * |
| TFF1 | columnar (intestinal) | 205009_at | 8.2017486 | 1.75e−05 * | 8070579 | 6.4595337 | 1.46e−12 * | 205009_at | 5.6843253 | 0.010407 * |
| TFF2 | columnar (intestinal) | 214476_at | 7.6665729 | 4.86e−05 * | 8070574 | 5.2354248 | 1.23e−08 * | 214476_at | 5.8714482 | 0.006909 * |
| TFF3 | columnar (intestinal) | 204623_at | 8.9897857 | 9.11e−08 * | 8070567 | 2.2346355 | 2.20e−04 * | 204623_at | 3.3738183 | 0.110978 |
| VIL1 | columnar (intestinal) | 209950_s_at | 5.8340643 | 8.63e−09 * | 8078665 | 2.2711873 | 1.88e−08 * | 209950_s_at | 2.5215122 | 0.025483 * |
| MUC1 | columnar (intestinal) | 213693_s_at | 1.5493643 | 1.21e−01 | 7920642 | 1.9449625 | 1.69e−05 * | 213693_s_at | 1.1435938 | 0.427828 |
| MUC2 | columnar (intestinal) | 204673_at | 6.7226214 | 3.16e−06 * | 7937560 | 2.1981597 | 2.77e−03 * | 204673_at | 2.9508572 | 0.271622 |
| MUC3A/B | columnar (intestinal) | 217117_x_at | 0.7757457 | 9.80e−02 | 8135015 | 4.3127432 | 6.68e−09 * | 217117_x_at | 0.9212935 | 0.225325 |
| MUC4 | columnar (intestinal) | 217109_at | −1.07354 | 1.13e−01 | 8092978 | 0.1271057 | 8.92e−01 | 204895_x_at | 1.903752 | 0.360547 |
| MUC5ac | columnar (intestinal) | 214385_s_at | 8.1766871 | 8.25e−07 * | not included in the database | 214385_s_at | 7.1466461 | 0.005318 * | ||
| MUC5B | columnar (intestinal) | 213432_at | 2.7593857 | 4.75e−02 * | 7937612 | 1.6075105 | 2.00e−03 * | 213432_at | 2.3107749 | 0.510519 |
| MUC6 | columnar (intestinal) | 214133_at | 3.1026371 | 7.45e−03 * | 7945595 | 5.9384813 | 1.46e−11 * | 214133_at | 3.4098322 | 0.017934 * |
| MUC12 | columnar (intestinal) | not included in the database | 8135033 | 2.2172345 | 1.33e−03 * | not included in the database | ||||
| MUC13 | columnar (intestinal) | 218687_s_at | 7.3541829 | 5.65e−10 * | 8090180 | 7.3474513 | 1.87e−11 * | 218687_s_at | 3.6273263 | 0.031468 * |
| MUC15 | columnar (intestinal) | not included in the database | 7947156 | −4.7653307 | 4.28e−10 * | not included in the database | ||||
| MUC17 | columnar (intestinal) | not included in the database | 8135048 | 5.953779 | 6.32e−08 * | not included in the database | ||||
| MUC21 | columnar (intestinal) | not included in the database | 8177931 | −5.732196 | 5.46e−07 * | not included in the database | ||||