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Structure and biosynthesis of PrPC. (A) Structural configuration of PrPC. Arabic numbers indicate positions of amino acids. (B) Biosynthetic pathways of PrPC, including the vesicle transport pathway from the ER to the plasma membrane, particularly raft domains, and the clathrin- or caveolae-dependent endocytic pathway, which connects to recycling pathway or degradation pathway to lysosomes.
