Table 1.

Aminoglycoside susceptibility of E. coli aac(3)-IV.

	E. coli Clinical aac(3)-IV Isolates				E. coli Recombinant aac(3)-IV Strains
	ATCC	AG173	AG380	AG381		Promoter Strength
Aminoglycoside	25,922				WT	+	++	+++
Apramycin	4	256–512	>512	>512	2	128	>512	>512
Gentamicin	0.5–1	8–16	32–64	64–128	0.25	8	64	128–256
Tobramycin	0.5–1	32	64–128	128	0.5	16	128–256	256–512
Amikacin	2	1	2–4	4	0.5–1	0.25–0.5	0.25	0.25–0.5
Sisomicin	0.5	8–16	16	32	0.125–0.25	2	16–32	128
Netilmicin	0.5	8–16	32–64	32	0.125–0.25	4–8	32–64	128
Plazomicin	0.5–1	0.5–1	1	1–2	0.25–0.5	0.125	0.125–0.25	0.125
Paromomycin	4	8	8	16	1	2	16	64–128