Table 1.
The role of the exosomal protein cargo in thoracic cancers.
| Exosomal Component | Origin of the Exosomes | Role | Cancer | Ref. |
|---|---|---|---|---|
| TGF-ß1 | Hypoxic LC cell lines | NKG2D decrease NK inhibition |
LC | [36] |
| Vimentin | HBE cells | Invasion | LC | [39] |
| EGFR | Serum | EMT Cancer invasion Metastasis |
AD | [40] |
| HSP72 | Lung AC cell lines | MDSC promotion Immune suppression |
AD | [34] |
| LRG1 | NSCLC cell lines and tissues | Angiogenesis | NSCLC | [41] |
| NY-ESO | Plasma | Prognosis and overall survival | NSCLC | [42] |
| LRG1 | Urine | Diagnosis | NSCLC | [43] |
| CD151, CD171, TSPAN8 | Plasma | LC diagnosis following histological subtypes | NSCLC | [42] |
| EGFR | LC biopsies | Tolerogenic DCs, Treg Immune suppression |
NSCLC | [32] |
| PD-L1 | LC cells | T cell suppression | NSCLC | [35] |
| TGF-ß1 | Pleural effusions | NKG2D reduction NK and CD8+ T cells suppression |
MPM | [44] |
| CD39, CD73 | Pleural effusions | Adenosine production T cell suppression |
MPM | [38] |
| G6PD, ENO1 | Angiogenesis | MPM | [45] |
NSCLC: non-small cell lung cancer, LC: lung cancer, AD: adenocarcinoma, SCC: squamous cell carcinoma, CSE-HBE: cigarette smoke extract transformed human bronchial epithelial cells, MPM: malignant pleural mesothelioma, PAE: past asbestos exposure, TGFβ1: transforming growth factor, beta 1, EGFR: epidermal growth factor receptor, HSP72: heat shock 70kDa protein 1A, LRG1: leucine-rich alpha-2-glycoprotein 1, TSPAN8: tetraspanin 8.