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. 2020 Aug 26;21(17):6157. doi: 10.3390/ijms21176157

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Figure A3 — Dynasore inhibits endocytosis of LP-A96 without cytotoxicity. (A–C) Cell viability under each treatment was visualized using annexin V and propidium iodide. Cells were incubated for 1 h with complete media, 80 μM dynasore, or 50 μM digitonin. Cells treated with dynasore did not experience cell death. (D–F) Endocytosis of LP-A96 is restored after dynasore has been removed. Cells pre-treated with (D) DMSO or (E) dynasore were further incubated with 1 μM rhodamine-labeled LP-A96 for 15 min and imaged. (F) Cells incubated for additional 4 h in basal media after dynasore was removed were further incubated with 1 μM rhodamine-labeled LP-A96 for 15 min and imaged. (G) Fluorescence intensity changes show restoration of LP-A96 endocytosis after 4 h. **** p < 0.0001, ns: non-significant. Mean ± SD.