a, Metrnl mRNA across tissues with or without tamoxifen treatment. Samples were harvested two weeks after tamoxifen IP injections (N=5/group). b, Migration assays using LPS and IL-4-treated macrophages. c, FACS analysis of migrating M1 or (d) M2 differentiated macrophages to recombinant Metrnl protein (N=3/group). Two-tailed, unpaired Student’s t-test (a) and ANOVA with Tukey’s post hoc comparison (c, d). Data are presented as mean ± SE.