Clinical decision support system (CDSS) as a new approach to ASD children to screen and improve the age of diagnosis: Box (A) (training) shows the flowchart including all data used (survey, such as Child Health Improvement through Computer Automation system (CHICA), omics data and electronic medical records (EHR)) by machine learning model to classify patients. Once the model has been constructed with good accuracy, the clinician (box (B)) (prediction) will upload the patient data. An A.I. model will predict the class with an actionable result summarized in the clinical report. The result will generate subgroups based on the patient’s features, for example, high functioning (H), low functioning (L), and control group (C). This system might be used by clinicians to improve early diagnosis because it provides significant information about the features of the ASD patient.