Table 1.

Green tea can exhibit anti-Parkinson’s effect—in vitro evidence.

Sl. NO.	Model Used	Mode of Action	Reference
1	Cell free in vitro system	EGCG inhibits the aggregation of and induces disaggregation of α-synuclein	[50,51,52,53,54]
2	PC12 cells	EGCG protected PC12 cells from α-synuclein induced toxicity	[50]
3	AS-PC12 cells	EGCG protected AS-PC12 cells from Fe(III) induced toxicity by reducing the formation of ROS	[52]
4	NB SH-SY5Y cells	EGCG offered neuroprotection by PKC mediated degradation of pro-apoptotic protein Bad	[61]
5	CHO cells expressing DAT	EGCG prevented neurodegeneration by inhibiting the ability of dopamine transporters (DAT) to actively uptake MPP+ and being transported to presynaptic dopaminergic neurons	[63]
6	DAT-PC12 cells	EGCG induces the internalization of DAT through the activation of PKC thereby preventing the reuptake of dopamine from the synaptic cleft	[65]
7	Cell free in vitro system	EGCG treatment chelates Fe3+ and prevents the fibrillization and toxic oligomer formation	[71]
8	SN4741 cells	EGCG downregulates cell cycle proteins cyclin D1, E and helps in neurite outgrowth and neuronal differentiation	[74]
9	Primary neuronal and neuron-astrocyte cells	L-theanine, protected cells from dopamine-induced toxicity by inducing glutathione production	[84]
10	CGN culture	EGCG inhibited apoptosis of neuronal cultures from mitochondrial oxidative stressors	[88]
11	SH-SY5Y cells	EGCG protected cells from 6-OHDA induced neurotoxicity; suppressing the buildup of ROS, restoring MMP, and maintaining calcium homeostasis	[97]
12	PC12 cells	EGCG protects cells from Oxy-Hb induced stress; inhibits Ca2+-influx through voltage-gated calcium channels	[98]
13	PC12 cells	EGCG protected cells from MPTP toxicity by the activation of PGC-1α via SIRT-1 signaling	[102]
14	SH-SY5Y cells	L-theanine exhibited neuroprotective effect against rotenone and dieldrin toxicity by downregulating HO-1, caspase-3, inducing neurotrophic factors BDNF and GDNF and activating ERK1/2 pathway	[105]
15	SH-SY5Y cells	EGCG ameliorates 6-OHDA toxicity via Akt signaling pathway and prevents apoptosis by downregulating caspase-3 activity	[116]
16	SH-SY5Y cells	EGCG inhibits TRAIL ligand expression as well as TRAIL receptor DR5	[120]
17	Macrophage cells	EGCG protects macrophage cells from LPS induced toxicity by inducing the expression of IFN-γ	[123]
18	Neuronal cultures	Green tea extract attenuated 6-OHDA induced NF-κB activation and cell death	[134]