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Osmotin treatment positively modulates AD through the AdipoR1/AMPK/SIRT1 pathway. (a) Obesity reduces adiponectin and AdipoR1 expressions, which negatively modulate the AMPK/SIRT1 pathway and increase the AD biomarkers. (b) Osmotin treatment increases adiponectin and AdipoR1 expressions and reduces AD biomarkers through the AMPK/SIRT1 pathway.
