Figure 2.

Molecular mechanisms of FASN in cancer. Expression and activity of FASN can be regulated by the epidermal growth factor receptor (EGFR) family members, EGFR and epidermal growth factor receptor 2 (HER2). FASN is shown to regulate lipid synthesis, signaling of major oncogenic pathways (including phosphatidylinositol-3′-kinase (PI3K/AKT) and extracellular regulated kinase 1/2 (ERK1/2)) and modulate cellular mechanisms (including autophagy, DNA repair and transcription of Lysosome Biogenesis genes). FASN overexpression promotes proliferation and increases the metastatic potential of tumor cells.