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In vitro release profiles of AmB from chitosan nanoparticles at 37 °C. (A) AmB-CH-Dex in PBS (pH of 5, 6.5 or 7.5) and mouse (BALB/c) plasma, (B) AmB-CH-TPP in PBS (pH of 5, 6.5 or 7.5) and mouse (BALB/c) plasma. (C) A comparison of AmB release from AmB solution, AmB-CH-TPP and AmB-CH-Dex nanoparticles in PBS at pH 5 and 7.5. Data expressed as mean +/− SD (experiment was reproduced three times with confirmed similar data). AmB-CH-TPP size = 69 ± 8 nm and AmB-CH-Dex size = 174 ± 8 nm.
