Skip to main content
. 2020 Sep 2;25(17):4002. doi: 10.3390/molecules25174002

Figure 3.

Figure 3

Multiple dose skin pharmacokinetics of AmB-CH-TPP nanoparticles and AmBisome. L. major-infected BALB/c mice received intravenous doses of AmBisome (G3, 10 mg/kg/QAD for 10 days; i.v.) and AmB-CH-TPP nanoparticles (G5, 5 mg of AmB/kg/QAD for 10 days; i.v.). 24 h after the last dosing, AmB levels in skin were determined. The CL lesion was localized on the rump, while the back skin of same mice was used as lesion-free, healthy control site. Each point represents the mean and standard error of the mean (n = 5 per group). (A) represents intralesional AmB and (B) represents a comparison between infected and uninfected skin AmB concentration. The data represent the mean ± standard error. ANOVA followed by Tukey’s multiple-comparison tests was used to compare outcomes among the groups. A p-value < 0.05 was considered statistically significant ((*) p < 0.05 and (**) p < 0.05).