Table 2 |.
Performance of elastography modalities in patients with NAFLD
| Study | n | Mean BMI (kg/m2) | Failure and/or unreliable rate (%)a | Patients with advanced (F3-F4) fibrosis (%) | AUROC for F3-F4 | Optimal cut-off for F3-F4 | Sensitivity/specificity | Refs |
|---|---|---|---|---|---|---|---|---|
| VCTE | ||||||||
| Chen | 111 | 40.3 | 22.7 | 20 | 0.87 | 7.6 kPa (M and XL) | 84/64 | 23 |
| Tapper | 164 | 32.3 | 27 | 18 | 0.93 | 9.9 kPa | 95/77 | 20 |
| Park | 104 | 30.4 | 6.7 | 17 | 0.8 | 7.3 kPa (M and XL) | 78/78 | 18 |
| Boursier | 588 | 31.7 | 9.3 | 39 | 0.83 | 8.7 kPa | 88/63 | 16 |
| Imajo | 142 | 28.1 | 10.5 | 32 | 0.88 | 11.4 kPa | 86/84 | 22 |
| Petta | 324 | 39.5% >30 | NA | 35 | 0.86 | 10.1 kPa | 78/78 | 54 |
| Cassinottob | 291 | 60.1% >30.0 | 23.4 | 43 | 0.86 | 8.2 and 12.5 kPa | 90/61 and 57/90 | 19 |
| Kumar | 120 | 26.1 | 14.9 | 23 | 0.94 | 9.0 kPa | 85/88 | 55 |
| Chan | 153 | 29.4 | 3.9 | 21 | NA | 8.0 kPa | 95/66 | 56 |
| Aykut | 88 | 30.3 | NA | 41 | 0.94 | 7.9 kPa | 96/90 | 57 |
| Naveau | 100 | 42.3 | 19 | 9 | 0.85 | 7.6 kPa | 100/74 | 58 |
| Gaia | 72 | 27.5 | NA | 34 | 0.76 | 8.0 kPa | 65/80 | 59 |
| Mahadeva | 131 | 32.8% >30.0 | 8 | 22 | 0.77 | 7.1 kPa | 70/67 | 60 |
| Wong | 193 | 28.9 | 25 | 30 | 0.78 (ITT) and 0.85 (PP) | 7.2 kPa (XL) | 74/75 (ITT) and 78/78 | 21 |
| Wong | 246 | 28.5% >30.0 | 10.2 | 23 | 0.93 | 8.7 kPa | (PP) 84/83 | 61 |
| MRE | ||||||||
| Chen | 111 | 40.3 | 4.5 | 20 | 0.92 | 3.6 kPa | 84/83 | 23 |
| Park | 104 | 30.4 | 0 | 17 | 0.87 | 3.0 kPa | 78/80 | 18 |
| Loomba | 100 | 32.1 | 0 | 15 | 0.92 | 3.8 kPa | 80/95 | 36 |
| Imajo | 142 | 28.1 | 0 | 32 | 0.89 | 4.8 kPa | 75/87 | 22 |
| Loomba | 117 | 32.4 | 0 | 19 | 0.92 | 3.6 kPa | 82/90 | 37 |
| Cui | 102 | 31.7 | 0 | 19 | 0.96 | 3.6 kPa | 92/90 | 39 |
| ARFI | ||||||||
| Cassinotto | 291 | 60.1% >30.0 | 19 | 43 | 0.84 | 1.15 and 1.53 m/s | 90/63 and 59/90 | 19 |
| Cui | 125 | 31.8 | 2.4 | 17 | 0.9 | 1.34 m/s | 95/74 | 31 |
| Palmeri | 172 | 68.6% >30.0 | 21.5 | 33 | 0.9 | 4.24 kPa (2.06 m/s) | 90/90 | 32 |
| SWE | ||||||||
| Cassinotto | 291 | 60.1% >30.0 | 20.3 | 43 | 0.89 | 8.3 and 10.7 kPa | 91/71 and 71/90 | 19 |
| Ochi | 181 | 26.5 | NA | 28 | 0.88 | 3.02c | 89/97 | 62 |
All relevant studies with >50 patients with NAFLD were included in this table. Some studies provided only the proportion of patients with BMI >30 kg/m2.
Failure and unreliable rates for VCTE studies are combined in this column; reliability criteria have not yet been determined for MRE, SWE or ARFI.
Used two cut-offs to maximize sensitivity and specificity.
Study used elastic ratio (the ratio of strain distribution in two selected regions of interest). ARFI, acoustic radiation force imaging; AUROC, area under the receiver operating characteristic; ITT; intention to treat; MRE, magnetic resonance elastography; NA, not available; PP, per protocol; SWE, shear-wave elastography; VCTE, vibration-controlled transient elastography.