Table 1.
Statistical analyses of liver histopathology scores.
| Histology variable | Control Fl/Fl mice (N = 35) | Ethanol Fl/Fl mice (N = 33) | Control LKO mice (N = 30) | Ethanol LKO mice (N = 31) | p |
|---|---|---|---|---|---|
| Histopathology score | |||||
| 0 | 23 (65.7)a | 22 (66.7) | 20 (66.7) | 12 (38.7) | 0.020b |
| 1 | 7 (20.0) | 6 (18.2) | 5 (16.7) | 11 (35.5) | |
| 2 | 2 (5.7) | 4 (12.1) | 3 (10.0) | 3 (9.7) | |
| 3 | 2 (5.7) | 1 (3.0) | 1 (3.3) | 3 (9.7) | |
| 4 | 1 (2.9) | 0 (0) | 0 (0) | 1 (3.2) | |
| 5 | 0 (0) | 0 (0) | 1 (3.3) | 1 (3.2) | |
| Steatosis grade | |||||
| 0 – <5% | 33 (94.3) | 27 (81.8) | 27 (90.0) | 16 (51.6) | 0.660c |
| 1 – 5–33% | 1 (2.85) | 6 (18.2) | 3 (10.0) | 12 (38.7) | 0.016d |
| 2 – 34–66% | 1 (2.85) | 0 (0) | 0 (0) | 3 (9.7) | |
| 3 – >66% | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
| Lobular inflammation | |||||
| 0 – none | 20 (57.1) | 24 (72.7) | 21 (70.0) | 19 (61.3) | 0.314e |
| 1 – <2 | 9 (25.7) | 7 (21.2) | 7 (23.3) | 10 (32.3) | 0.427f |
| 2 – 2–4 | 5 (14.3) | 1 (3.0) | 0 (0) | 1 (3.2) | |
| 3 – >4 | 1 (2.9) | 1 (3.0) | 2 (6.7) | 1 (3.2) | |
| Ballooning | |||||
| 0 – none | 35 (100) | 33 (100) | 27 (90) | 29 (93.5) | 0.093g |
| 1 – few | 0 (0) | 0 (0) | 3 (10) | 3 (9.7) | 0.108h |
| 2 – many | 0 (0) | 0 (0) | 0 (0) | 0 | |
Values are N (%).
Values of p are from an ordinal contingency analysis for each parameter; significant Genotype X Diet Interaction.
Values of p for steatosis are from a Fisher’s Exact Test comparing absence (steatosis grade 0) and presence (grade 1 + 2) in control-fed Fl/Fl vs. control-fed LKO mice.
Values of p for steatosis are from a Fisher’s Exact Test comparing absence (steatosis grade 0) and presence (1 + 2) in alcohol-fed Fl/Fl vs. alcohol-fed LKO mice.
Values of p for lobular inflammation are from a Fisher’s Exact Test comparing presence (1–3) or absence (0) of lobular inflammation in control-fed Fl/Fl vs. control-fed LKO mice.
Values of p for lobular inflammation are from a Fisher’s Exact Test comparing presence (1–3) or absence (0) of lobular inflammation in alcohol-fed Fl/Fl vs. alcohol-fed LKO mice.
Values of p for hepatocyte ballooning are from a Fisher’s Exact Test comparing presence or absence of ballooned hepatocytes in control-fed Fl/Fl vs. control-fed LKO mice.
Values of p for hepatocyte ballooning are from a Fisher’s Exact Test comparing presence or absence of ballooned hepatocytes in alcohol-fed Fl/Fl vs. alcohol-fed LKO mice.