Table 2.
Exposure concentrations and particle size distributions of generated aerosol for in vivo studies.
| Type of ENMs | Concentration of NPs used in Collison nebulizerb | Exposure aerosol concentration, mg/m3 |
Aerosol size distribution, GM, nm (GSD)a | Peak particle count/cm3 | |
|---|---|---|---|---|---|
| Toxicity evaluation | Dosimetry assessment | ||||
| ZnO | 0.3 mg/mL | 3.75 | 3.80 | 37.5 (1.78) | 2.46 × 106 |
| CuO | 1 mg/mL | 3.77 | 3.61 | 33.3 (1.70) | 2.05 × 106 |
| V2O5 | 1 mg/mL | 4.15 | 4.19 | 43.0 (1.71) | 5.26 × 106 |
| WO3 | 0.4 mg/mL | 3.24 | 2.95 | 77.6 (1.72) | 1.37 × 106 |
a
Geometric mean mobility diameter (GM) with geometric standard deviation (GSD).
b
The pressure and air flow through 6-jet Collison Nebulizer was the same for all ENMs evaluated: 20 psi and 12 L/min, respectively.