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B-cell and T-cell cross talk impacts quality of the antibody response. MyD88 signaling and recognition of bacterial antigens via the B-cell receptor (BcR) leads to B-cell cell activation and antigen presentation to naive T-cells via MHC class II molecules. Interleukin 6 (IL-6) and gamma interferon (IFN-γ) from B cells mediate the development of Th immunity. Th immunity in turn triggers activation and maturation of B cells and induces isotype switching of the antibody response.
