Fig. 1.

Correlations between the levels of CSF YKL-40 and neurogranin versus t-tau, p-tau, and Aβ₄₂. Correlations between CSF YKL-40 (A) and neurogranin (B) and the clinically established CSF biomarkers t-tau, p-tau, and Aβ₄₂ in FAD MC and NC. The solid lines indicate the linear-regression, the dotted lines represent the 95% confidence interval and the “r” represents the Pearson correlation coefficient when correlating Aβ₄₂ to YKL-40 and neurogranin and the Spearman correlation coefficient when correlating t-tau and p-tau to YKL-40 and neurogranin. All the correlations were positive and significant except for the correlation between YKL-40 and Aβ₄₂ in the MC group and between neurogranin and Aβ₄₂, also in the MC group. The symbols represent individual values (filled symbols NC and white symbols MC) CSF, cerebrospinal fluid; FAD, familial Alzheimer’s disease; MC, mutation carriers; NC, non-carriers.