. Author manuscript; available in PMC: 2020 Sep 21.

Published in final edited form as: Gastroenterology. 2019 Jan 18;156(5):1264–1281.e4. doi: 10.1053/j.gastro.2018.12.036

Table 4.

Performances of Transient Elastography for the Diagnosis of Advanced Fibrosis and Cirrhosis in Adult Patients With Nonalcoholic Fatty Liver Disease, Taking Liver Biopsy as Reference

Authors	Year	Design	Patients, n	Age, y	BMI, kg/m²	Scoring system	End point	Prevalence, %	Cutoff, kPa	AUC	Se, %	Sp, %	Failure or unreliable, %	Probe
Petta¹¹¹	2015	R	179	45 ± 13	29.3 ± 4.1	Kleiner	F3-F4	23	7.9/9.6	0.86	85	81	13.0	M
			142	44 ± 12	27.4 ± 3.7		F3-F4	20	7.9/9.6	0.85	68	86	23.0	M
Cassinotto¹⁰⁹	2016	P	291	57 ± 12	32.1 ± 6.0	NASH-CRN	F3-F4	43	8.2/12.5	0.86	90/57	61/90	22.0	M
							F4	17	9.5/16.1	0.87	92/65	62/90
Tapper¹¹²	2016	P	164	51 ± 13	32.2^a	Brunt	F3-F4	18	9.9	0.93	95	77	26.8	M
							F4	—
Boursier¹⁰⁷	2016	R	452	56 ± 12	31.1 ± 5.2	NASH-CRN	F3-F4	38	8.7	0.83	88	63	14.1	M
							F4	13	—	0.87	—	—
Imajo³⁹	2016	P	142 (10 C)	57 ± 15	28.1 ± 4.6	Brunt	F3-F4	32	11.4	0.88	86	84	11.0	M
							F4	8	14.0	0.92	100	76
Petta¹¹⁵	2017	R	324	54 ± 13	—	Kleiner	F3-F4	35	10.1	0.86	78	78	—	M
Park⁴³	2017	P	104	51 ± 15	30.4 ± 5.2	NASH-CRN	F3-F4	20	7.3	0.80	78	72	—	M
							F4	8	6.9	0.69	63	66	6.7	XL
Chen¹¹⁰	2017	P	111	48^a	40.3	Brunt	F3-F4	20	7.6	0.87	84	64	—	M
							F4	10	14.6	0.92	82	92	18.7	XL
Petta¹⁶⁸	2017	R	761	51 ± 13	29.6 ± 4.9	Kleiner	F3-F4	31	7.9/9.6	0.86	90/74	65/81	—	M
Siddiqui⁴⁵	2018	P	393	51 ± 11	34.4 ± 6.4	NASH-CRN	F3-F4	32	8.6	0.83	80	74	—	M
							F4	9	13.1	0.93	89	86	5.0	XL

AUC, area under the curve; C, controls; NASH-CRN, nonalcoholic steatohepatitis clinical research network; P, prospective; R, retrospective; Se, sensitivity; Sp, specificity.

Median.