Network of action of the investigated genes. A2AR, adenosine A2A receptor; AMP, adenosine monophosphate; APC, antigen-presenting cell; B7, B-lymphocyte-activation antigen B7; CCL2, chemokine (C-C motif) ligand 2; CCR2, C-C chemokine receptor 2; CTLA4, cytotoxic T-lymphocyte antigen 4; MHC II, major histocompatibility complex II; PDCD1, programmed cell death 1; TC, tumor cell; Treg, T-regulatory cell.