Table 3.
Gene variants and recurrence-free survival and overall survival
| Recurrence-free survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|
| n | Median (95%CI) | Univariable HR (95% CI) | Multivariable HR (95% CI) | 3-year rate | Univariable HR (95% CI) | Multivariable HR (95% CI) | |
| CCL2 rs4586 | |||||||
| A/A | 55 | 11.7 (8.3, 16.0) | 1 (reference) | 1 (reference) | 0.63 ± 0.08 | 1 (reference) | 1 (reference) |
| A/G | 68 | 13.5 (10.1, 22.5) | 0.87 (0.57, 1.35) | 1.05 (0.67, 1.64) | 0.72 ± 0.07 | 0.84 (0.45, 1.59) | 1.08 (0.56, 2.07) |
| G/G | 22 | 10.1 (4.6, 14.3) | 1.31 (0.73, 2.34) | 1.47 (0.80, 2.69) | 0.83 ± 0.14 | 0.61 (0.21, 1.79) | 1.05 (0.38, 2.89) |
| P-valuea | 0.37 | 0.44 | 0.83 | 0.97 | |||
| LAG3 rs3782735 | |||||||
| A/A | 58 | 11.2 (8.4, 18.5) | 1 (reference) | 1 (reference) | 0.66 ± 0.08 | 1 (reference) | 1 (reference) |
| A/G | 70 | 13.0 (9.5, 16.5) | 0.92 (0.60, 1.40) | 0.89 (0.58, 1.37) | 0.77 ± 0.07 | 0.82 (0.42, 1.59) | 0.96 (0.50, 1.85) |
| G/G | 20 | 11.0 (4.1, 81.2) | 0.99 (0.53, 1.84) | 0.97 (0.51, 1.85) | 0.59 ± 0.14 | 1.61 (0.72, 3.58) | 1.68 (0.74, 3.83) |
| P-valuea | 0.92 | 0.87 | 0.35 | 0.38 | |||
| NT5E rs6922 | |||||||
| G/G | 61 | 13.0 (9.2, 18.6) | 1 (reference) | 1 (reference) | 0.72 ± 0.08 | 1 (reference) | 1 (reference) |
| G/T | 72 | 10.3 (8.4, 16.3) | 1.11 (0.73, 1.68) | 0.89 (0.58, 1.37) | 0.66 ± 0.07 | 1.28 (0.68, 2.40) | 1.09 (0.58, 2.07) |
| T/T | 15 | 14.0 (6.5, 16.6) | 1.02 (0.51, 2.05) | 0.87 (0.42, 1.79) | 0.75 ± 0.17 | 0.74 (0.22, 2.52) | 0.64 (0.18, 2.24) |
| P-valuea | 0.89 | 0.85 | 0.54 | 0.70 | |||
| PDCD1 rs10204525 | |||||||
| C/C | 119 | 11.1 (9.5, 14.3) | 1 (reference) | 1 (reference) | 0.69 ± 0.05 | 1 (reference) | 1 (reference) |
| C/T | 25 | ||||||
| T/T | 3 | ||||||
| C/T or T/T | 28 | 16.0 (9.2, 77.3) | 0.68 (0.39, 1.17) | 0.69 (0.40, 1.21) | 0.74 ± 0.13 | 0.56 (0.22, 1.41) | 0.61 (0.24, 1.58) |
| P-valuea | 0.16 | 0.20 | 0.17 | 0.31 | |||
| CCR2 rs3092964 | |||||||
| T/T | 90 | 10.8 (8.4, 14.4) | 1 (reference) | 1 (reference) | 0.68 ± 0.06 | 1 (reference) | 1 (reference) |
| T/C | 47 | 14.3 (10.4, 22.1) | 0.85 (0.55, 1.29) | 0.87 (0.56, 1.36) | 0.78 ± 0.08 | 0.91 (0.47, 1.77) | 0.82 (0.42, 1.61) |
| C/C | 10 | 7.8 (4.0, 46.3) | 1.17 (0.53, 2.55) | 1.09 (0.49, 2.41) | 0.40 ± 0.15 | 2.17 (0.83, 5.66) | 1.79 (0.66, 4.85) |
| P-valuea | 0.64 | 0.78 | 0.24 | 0.38 | |||
| IDO1 rs9657182 | |||||||
| A/A | 48 | 11.7 (7.6, 27.9) | 1 (reference) | 1 (reference) | 0.66 ± 0.09 | 1 (reference) | 1 (reference) |
| A/G | 75 | 11.0 (8.7, 15.1) | 1.19 (0.76, 1.88) | 1.00 (0.63, 1.59) | 0.70 ± 0.07 | 0.86 (0.44, 1.68) | 0.77 (0.40, 1.50) |
| G/G | 26 | 16.5 (6.5, 29.1) | 0.96 (0.53, 1.76) | 0.80 (0.41, 1.54) | 0.75 ± 0.13 | 0.76 (0.31, 1.90) | 0.80 (0.32, 2.01) |
| P-valuea | 0.64 | 0.74 | 0.75 | 0.74 | |||
| IDO1 rs3739319 | |||||||
| G/G or G/A | 114 | 13.0 (10.5,17.8) | 1 (reference) | 1 (reference) | 0.75 ± 0.05 | 1 (reference) | 1 (reference) |
| G/G | 43 | ||||||
| G/A | 71 | ||||||
| A/A | 32 | 8.4 (4.9,14.0) | 1.48 (0.93,2.34) | 1.13 (0.68,1.88) | 0.49 ± 0.11 | 2.52 (1.33,4.80) | 2.04 (1.03,4.03) |
| P-valuea | 0.093 | 0.64 | 0.007 | 0.040 | |||
| CD274 rs2297137 | |||||||
| G/G | 88 | 12.3 (10.1, 16.3) | 1 (reference) | 1 (reference) | 0.71 ± 0.06 | 1 (reference) | 1 (reference) |
| G/A | 49 | ||||||
| A/A | 8 | ||||||
| G/A or A/A | 57 | 11.2 (8.4, 19.5) | 0.87 (0.57, 1.31) | 0.84 (0.54, 1.31) | 0.66 ± 0.08 | 1.08 (0.58, 2.00) | 1.11 (0.59, 2.10) |
| P-valuea | 0.50 | 0.44 | 0.76 | 0.74 | |||
| CTLA4 rs231777 | |||||||
| C/C | 111 | 12.8 (10.1, 15.1) | 1 (reference) | 1 (reference) | 0.67 ± 0.06 | 1 (reference) | 1 (reference) |
| C/T | 33 | ||||||
| T/T | 4 | ||||||
| C/T or T/T | 37 | 11.7 (6.7, 18.6) | 1.17 (0.75, 1.81) | 1.11 (0.70, 1.75) | 0.80 ± 0.10 | 0.85 (0.42, 1.73) | 0.65 (0.31, 1.36) |
| P-valuea | 0.48 | 0.65 | 0.55 | 0.25 | |||
| CD24 rs8734 | |||||||
| G/G | 79 | 10.8 (7.7, 14.3) | 1 (reference) | 1 (reference) | 0.63 ± 0.07 | 1 (reference) | 1 (reference) |
| G/A | 64 | ||||||
| A/A | 4 | ||||||
| G/A or A/A | 68 | 11.7 (10.1, 22.6) | 0.79 (0.53, 1.17) | 0.74 (0.49, 1.13) | 0.76 ± 0.07 | 0.53 (0.28, 0.97) | 0.55 (0.30, 1.01) |
| P-valuea | 0.24 | 0.17 | 0.042 | 0.054 | |||
Abbreviations: A, adenine; C, cytosine; CI, confidence interval; G, guanine; HR, hazard ratio; T, thymine.
a
Based on log-rank test in the univariable analysis and Wald test in the multivariable analysis within Cox regression model. Multivariable Cox regression model was adjusted for age (< 65 vs ⩾ 65 years), number of metastases (1–2 vs > 2), size of metastases (1–50 mm vs > 50 mm), and time since diagnosis of CRC (< 6 months, 6–12 months, 1–2 years and > 2 years).