Table 4.
Gene variants and radiological and histological response
| Radiological response |
Histological response |
|||||
|---|---|---|---|---|---|---|
| n | PR | SD | MjHR | PHR | NHR | |
| CCL2 rs4586 | ||||||
| A/A | 55 | 42 (76%) | 13 (24%) | 20 (37%) | 14 (26%) | 20 (37%) |
| A/G | 68 | 56 (85%) | 10 (15%) | 25 (38%) | 21 (32%) | 20 (30%) |
| G/G | 22 | 20 (95%) | 1 (5%) | 9 (41%) | 4 (18%) | 9 (41%) |
| P-valuea | 0.14 | 0.87 | ||||
| LAG3 rs3782735 | ||||||
| A/A | 58 | 44 (77%) | 13 (23%) | 19 (34%) | 19 (34%) | 18 (32%) |
| A/G | 70 | 60 (87%) | 9 (13%) | 26 (38%) | 17 (25%) | 26 (38%) |
| G/G | 20 | 16 (84%) | 3 (16%) | 10 (50%) | 4 (20%) | 6 (30%) |
| P-valuea | 0.35 | 0.64 | ||||
| NT5E rs6922 | ||||||
| G/G | 61 | 51 (85%) | 9 (15%) | 21 (34%) | 18 (30%) | 22 (36%) |
| G/T | 72 | 57 (81%) | 13 (19%) | 27 (39%) | 18 (26%) | 24 (35%) |
| T/T | 15 | 13 (87%) | 2 (13%) | 7 (47%) | 4 (27%) | 4 (27%) |
| P-valuea | 0.85 | 0.67 | ||||
| PDCD1 rs10204525 | ||||||
| C/C | 119 | 97 (83%) | 20 (17%) | 41 (35%) | 34 (29%) | 41 (35%) |
| C/T | 25 | |||||
| T/T | 3 | |||||
| C/T or T/T | 28 | 22 (81%) | 5 (19%) | 14 (50%) | 6 (21%) | 8 (29%) |
| P-valuea | 0.79 | 0.23 | ||||
| CCR2 rs3092964 | ||||||
| T/T | 90 | 76 (85%) | 13 (15%) | 32 (36%) | 29 (33%) | 28 (31%) |
| T/C | 47 | 36 (80%) | 9 (20%) | 20 (43%) | 8 (17%) | 18 (39%) |
| C/C | 10 | 7 (70%) | 3 (30%) | 3 (33%) | 2 (22%) | 4 (44%) |
| P-valuea | 0.36 | 0.87 | ||||
| IDO1 rs9657182 | ||||||
| A/A | 48 | 37 (77%) | 11 (23%) | 14 (29%) | 15 (31%) | 19 (40%) |
| A/G | 75 | 62 (83%) | 13 (17%) | 32 (44%) | 18 (25%) | 23 (32%) |
| G/G | 26 | 22 (96%) | 1 (4%) | 10 (40%) | 7 (28%) | 8 (32%) |
| P-valuea | 0.14 | 0.35 | ||||
| IDO1 rs3739319 | ||||||
| G/G or G/A | 114 | 92 (83%) | 19 (17%) | 44 (39%) | 30 (27%) | 39 (35%) |
| G/G | 43 | |||||
| G/A | 71 | |||||
| A/A | 32 | 27 (84%) | 5 (16%) | 12 (40%) | 9 (30%) | 9 (30%) |
| P-valuea | 1.00 | 0.75 | ||||
| CD274 rs2297137 | ||||||
| G/G | 88 | 74 (85%) | 13 (15%) | 28 (33%) | 28 (33%) | 30 (35%) |
| G/A | 49 | |||||
| A/A | 8 | |||||
| G/A or A/A | 57 | 44 (80%) | 11 (20%) | 26 (46%) | 11 (20%) | 19 (34%) |
| P-valuea | 0.49 | 0.31 | ||||
| CTLA4 rs231777 | ||||||
| C/C | 111 | 92 (85%) | 16 (15%) | 42 (39%) | 27 (25%) | 40 (37%) |
| C/T | 33 | |||||
| T/T | 4 | |||||
| C/T or T/T | 37 | 29 (78%) | 8 (22%) | 14 (39%) | 12 (33%) | 10 (28%) |
| P-valuea | 0.44 | 0.57 | ||||
| CD24 rs8734 | ||||||
| G/G | 79 | 62 (79%) | 16 (21%) | 26 (34%) | 27 (35%) | 24 (31%) |
| G/A | 64 | |||||
| A/A | 4 | |||||
| G/A or A/A | 68 | 57 (86%) | 9 (14%) | 28 (42%) | 13 (19%) | 26 (39%) |
| P-valuea | 0.38 | 0.98 | ||||
Abbreviations: A, adenine; C, cytosine; G, guanine; MjHR, major histological response; NHR, no histological response; PHR, partial histological response; PR, partial response; SD, stable disease; T, thymine.
a
Based on the Cochran–Mantel–Haenszel test for histological response and Fisher’s exact test for radiological response.