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. Author manuscript; available in PMC: 2020 Sep 21.
Published in final edited form as: Cancer Treat Rev. 2018 Dec 3;73:10–19. doi: 10.1016/j.ctrv.2018.12.001

Figure 2.

Figure 2.

The role of B cell-related pathways in secondary lymphoid organs and cancer cells.

B cell/Tfh cell interaction in SLOs is the basis of adaptive immune response. CCL19, -21/CCR7 axis and CXCL13/CXCR5 axis play the important role in immune cells migration to SLOs or tumor sites to activate immune response. On the contrary, CCL19, -21/CCR7 axis and CXCL13/CXCR5 axis in cancer cells also play the role of creating a protumorigenic micro-environment.

Abbreviations: B0, naive B cell; DC, dendritic cell; HEV, endothelial venule; LECs, endothelial cells; NK, natural killer cell; SLOs, secondary lymphoid organs; Tfh, T follicular helper cell; Tfr, T follicular regulatory cell; Th0, naive T cell; Th1, T helper 1 cell; Treg, regulatory T cell.