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. 2020 Apr 29;46(5):1172–1181. doi: 10.1093/schbul/sbaa052

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — Transcript expression levels of the genes coding for S1P receptors. (A) Absolute quantification of the expression levels of genes for S1P receptors (S1PR/S1pr1-5) in postmortem human (control, n = 6) and mouse brains (C57/BL6J, n = 3) by digital PCR. (B) Transcript expression levels for S1P receptors in the corpus callosum of patients with schizophrenia (n = 91) and controls (n = 90). The data were normalized with the geometric mean of the 2 internal control genes (GAPDH and B2M) and are represented as the mean ± SEM. *P < .05. Difference between 2 groups was analyzed by Mann-Whitney U test. (C) Correlation between S1P content and transcript expression levels for S1PR1 and S1PR5 in the corpus callosum of patients with schizophrenia and controls (Spearman’s rank correlation coefficient). CC, corpus callosum; BA8, Brodmann area 8; FC, frontal cortex.