Figure 1.

Anatomical connectivity between cortex and thalamus in psychosis. (A) Thalamic anatomical connectivity with the prefrontal cortex (PFC) is reduced in both schizophrenia and psychotic bipolar disorder. In contrast, anatomical connectivity between thalamus and somatosensory cortex is increased in schizophrenia and psychotic bipolar disorder. Occipital cortex connectivity with the thalamus is elevated in schizophrenia compared with both healthy individuals and psychotic bipolar disorder. (B) Within the combined psychotic disorders group (ie, schizophrenia plus psychotic bipolar disorder), PFC anatomical connectivity with the thalamus is reduced in both chronic and early-stage psychosis. Elevated somatosensory anatomical connectivity is present only in early-stage psychosis. See text and supplementary material for complete statistical results. *P < .05.