Table 2.
Drugs that rescue the GCX.
| Compound | Possible mechanisms | References |
|---|---|---|
| Albumin/S1P | Regenerate GCX, inhibit shedding | 4, 11, 132, 235, 238 |
| Sulodexide | Supplement GCX, inhibit degrading enzymes | 30, 112, 123, 193, 194, 214 |
| Rhamnan Sulfate | Enhances HS synthesis | 23, 156, 197 |
| Sevoflurane | Inhibit shedding, increase GCX regeneration | 5, 24, 93, 113 |
| Biomimetic Nanoparticles | Replace shed GCX | 223, 243 |
| ALM BHB/M P-188 | Inhibit shedding | 206 |
| Blueberry Metabolites | Regenerate GCX | 13, 16, 38 |
| Empagliflozin | Regenerate GCX | 34, 83 |
| Metformin | Regenerate GCX | 8, 53, 102, 204, 214 |
S1P sphingosine-1 phosphate, ALM adenosine + lidocaine + Mg, BHB/M beta-hydroxybutryrate + melatonin, P-188 poloxamer 188