Fig. 5.

Heatmap presenting the associations between COVID-19 ongoing drugs and 30 human tissues predicted by network proximity approach (A) and GSEA approach (B). Hypothesis for the two methods: A Network proximity, a drug would have a potential specific tissue toxicity if there is a significant network distance between its drug module and tissue module in human protein–protein interactome; B GSEA, a drug would have a correlation with a specific tissue if its regulatory proteins tend to be the specific high expressed proteins in this tissue. The color key indicates the significance (-log(adj-P) value or Z-score) of drug-tissue toxicity associations, red: highest and blue: lowest. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)