Figure 1.

Surgery plus sevoflurane anesthesia, but not anesthesia alone, impaired spatial memory in APP/PS1 mice. (A) The mice in surgery (S) group, but not anesthesia group, had a longer escape latency on postoperative day two and three compared with control (Con) group. (B) There was no difference among three groups in swimming speeds during the training and probe tests. (C) The platform crossings of S group were significantly decreased on postoperative day three compared with Con group. (D) The trajectory of probe trial test of three groups on postoperative day three. Results were presented as mean ± SEM (n = 10). Two-way ANOVA with post-hoc Bonferroni test, *p<0.05, **p<0.01 compared with Con group, ^#p<0.05,^{# #}p<0.05 compared with anesthesia group.