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. 2020 Oct 1;11(5):1029–1045. doi: 10.14336/AD.2020.0106

Figure 7.

Figure 7.

XOS intervention attenuated neuroinflammatory response induced by surgery. (A) IL-1β, IL-6 and IL-10 levels were increased in the hippocampus of mice in the S group compared with Con group, and XOS intervention attenuated the increase of IL-1β, IL-6 and IL-10 after surgery. The level of TNF-α was not changed among four groups. (B and C) The immunofluorescence showed an increase of Iba-1 positive cells in CA1 region and dentate gyrus in S group compared with Con group, and XOS intervention attenuated the increase of Iba-1 positive cells after surgery. (D) Western blot analysis showed that Iba-1 expression was increased in S group compared with Con group, and XOS intervention attenuated the increase of Iba-1 expression after surgery. (E) The expression of TREM2 was decreased in S group compared with Con group, and XOS intervention attenuated the decrease of TREM2 expression after surgery. Results were presented as mean ± SEM (n = 6). Two-way ANOVA with post hoc Bonferroni test, *p<0.05, **p<0.01, ***p<0.001.