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. 2020 Sep 2;9:e59035. doi: 10.7554/eLife.59035

Figure 4. A coarse-grained model was constructed to simulate the spatial-temporal process of E-cad clustering.

Figure 4.

(A) E-cad extracellular domains (orange), nonspecific and specific cis-interactions. Cis-donor sites are labeled in purple, and cis-acceptor sites are labeled in red. A structural model of the E-cad is shown on the right side. Ectodomain structure with EC domains 1–5 numbered from the N-terminus. (B) Top view of initial configuration in the simulations. The number of E-cad molecules is equal to 200. (C) Top view of final configuration in the mutant system. (D) Top view of final configuration in the wild-type system.