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. 2020 Sep 17;14:3777–3786. doi: 10.2147/DDDT.S270025

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© 2020 Ur Rehman et al.

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Effect of 4-FBS 20, 40, 60mg/kg p.o. on the acquisition of nicotine-induced behavioral sensitization. BALB/c mice (n=6/group) were used in this protocol. On day 1, one-way ANOVA followed by Tukey’s test showed no significance between nicotine and 4-FBS-treated groups while on day 7, only 40mg/kg showed significant result *p < 0.05 compared to nicotine. After 3 days of abstinence, all three doses, ie, 20, 40, 60mg/kg showed significant reduction in locomotion **p<0.01, ***P<0.001 compared to nicotine. No significant difference was observed between saline and 4-FBS 20, 40 and, 60mg/kg on days 7 and 11.