Table 1.
Cox Regression Analysis of Predictive Factors for Disease-Free Survival in the Training Dataset Patients with LARC Following NCRT (n=169)
| Variables | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Sex, male/female | 0.757 | 0.406–1.411 | 0.381 | |||
| Age | 1.001 | 0.979–1.024 | 0.907 | |||
| ASA | 0.937 | 0.560–1.567 | 0.804 | |||
| Distance from the anal verge | 1.002 | 0.904–1.111 | 0.967 | |||
| Tumor size | 1.479 | 1.243–1.761 | <0.001 | 1.131 | 0.927–1.379 | 0.224 |
| Pathological T stage | 1.624 | 1.226–2.151 | 0.001 | 0.933 | 0.623–1.397 | 0.737 |
| Pathological N stage | 2.374 | 1.686–3.344 | <0.001 | 1.810 | 1.159–2.827 | 0.009 |
| AJCC grade | 1.575 | 1.146–2.167 | 0.005 | 0.980 | 0.643–1.494 | 0.926 |
| Interval time between NCRT and surgery | 0.973 | 0.847–1.117 | 0.696 | |||
| DRM involvement | 5.982 | 0.801–44.651 | 0.081 | |||
| CRM involvement | 1.786 | 0.246–12.960 | 0.566 | |||
| Pre-NCRT cT stage | 1.161 | 0.697–1.932 | 0.566 | |||
| Pre-NCRT cN stage | 0.889 | 0.352–2.244 | 0.803 | |||
| Organ preservation | 1.377 | 0.585–3.240 | 0.464 | |||
| Pre-NCRT CEA level | 1.131 | 0.641 −1.996 | 0.671 | |||
| Post-NCRT CEA level | 1.515 | 0.772 −2.970 | 0.227 | |||
| Pre-NCRT FOXK1 expression | 7.847 | 4.244–14.510 | <0.001 | 5.831 | 2.925–11.625 | <0.001 |
| Pre-NCRT FOXK2 expression | 2.789 | 1.552–5.011 | 0.001 | 2.390 | 1.272–4.491 | 0.007 |
| Postoperative complications | 1.257 | 0.626–2.522 | 0.521 | |||
| Nerval invasion | 5.968 | 1.419–25.092 | 0.015 | 3.453 | 0.778–15.325 | 0.103 |
| Vascular invasion | 0.049 | 0.000–2166.539 | 0.580 | |||
| Tumor differentiation | 2.518 | 1.215–5.219 | 0.013 | 1.060 | 0.452–2.487 | 0.894 |
| Histopathology | 0.227 | |||||
| Expanding | Reference | Reference | ||||
| Infiltrating | 0.570 | 0.177–1.841 | 0.348 | |||
| Ulcering | 1.401 | 0.282–6.947 | 0.680 | |||
Abbreviations: LARC, locally advanced rectal cancer; NCRT, neoadjuvant chemoradiotherapy; HR, hazard ratio; CI, confidential interval; ASA, American Society of Anesthesiologists; AJCC, American Joint Committee on Cancer; CEA, carcinoembryonic antigen; CRM, circumferential resection margin; DRM, distal resection margin.