Table 2.
Cox Regression Analysis of Predictive Factors for Overall Survival in the Training Dataset Patients with LARC Following NCRT (n=169)
| Variables | Univariate Analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Sex, male/female | 0.919 | 0.461–1.828 | 0.808 | |||
| Age | 0.990 | 0.965–1.016 | 0.466 | |||
| ASA | 0.903 | 0.496–1.643 | 0.739 | |||
| Distance from the anal verge | 1.007 | 0.897–1.130 | 0.906 | |||
| Tumor size | 1.497 | 1.218–1.840 | <0.001 | 1.138 | 0.885–1.464 | 0.313 |
| Pathological T stage | 1.549 | 1.136–2.110 | 0.006 | 0.824 | 0.515–1.320 | 0.422 |
| Pathological N stage | 2.689 | 1.837–3.937 | <0.001 | 2.136 | 1.242–3.674 | 0.006 |
| Pathological M stage | 3.881 | 1.371–10.981 | 0.011 | 0.532 | 0.143–1.983 | 0.347 |
| AJCC grade | 1.612 | 1.122–2.314 | 0.010 | 0.958 | 0.585–1.569 | 0.864 |
| Interval time between NCRT and surgery | 0.935 | 0.798–1.094 | 0.401 | |||
| DRM involvement | 8.961 | 1.143–70.263 | 0.037 | 1.002 | 0.113–8.852 | 0.999 |
| CRM involvement | 2.150 | 0.294–15.700 | 0.450 | |||
| Pre-NCRT cT stage | 1.071 | 0.602–1.904 | 0.816 | |||
| Pre-NCRT cN stage | 2.065 | 0.496–8.589 | 0.319 | |||
| Organ preservation | 1.714 | 0.714–4.113 | 0.228 | |||
| Pre-NCRT CEA level | 1.127 | 0.590 −2.152 | 0.716 | |||
| Post-NCRT CEA level | 2.005 | 0.970–4.143 | 0.060 | |||
| Pre-NCRT FOXK1 expression | 7.181 | 3.541–14.562 | <0.001 | 5.353 | 2.331–12.296 | <0.001 |
| Pre-NCRT FOXK2 expression | 2.798 | 1.450–5.401 | 0.002 | 2.208 | 1.010–4.824 | 0.047 |
| Postoperative complications | 0.877 | 0.366–2.103 | 0.769 | |||
| Nerval invasion | 9.014 | 2.110–38.504 | 0.003 | 4.943 | 1.062–23.011 | 0.042 |
| Vascular invasion | 0.049 | 0.000–1122.150 | 0.632 | |||
| Tumor differentiation | 2.909 | 1.327–6.376 | 0.008 | 1.171 | 0.428–3.202 | 0.758 |
| Histopathology | 0.137 | |||||
| Expanding | Reference | Reference | ||||
| Infiltrating | 0.598 | 0.143–2.497 | 0.481 | |||
| Ulcering | 1.899 | 0.317–11.368 | 0.482 | |||
Abbreviations: LARC, locally advanced rectal cancer; NCRT, neoadjuvant chemoradiotherapy; HR, hazard ratio; CI, confidential interval; ASA, American Society of Anesthesiologists; AJCC, American Joint Committee on Cancer; CEA, carcinoembryonic antigen; CRM, circumferential resection margin; DRM, distal resection margin.