Table 4.
Summary of hematology in 90-day dietary toxicity study with Dry Mankai in rats.
| Male | Female | |||||||
|---|---|---|---|---|---|---|---|---|
| Dose (w/w %) | 0 (Control) | 5 | 10 | 20 | 0 (Control) | 5 | 10 | 20 |
| Number of rats | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 |
| RBC (104/μL) | 866 ± 37 | 873 ± 37 | 864 ± 34 | 858 ± 32 | 779 ± 16 | 799 ± 22 | 761 ± 28 | 779 ± 32 |
| HGB (g/dL) | 15.1 ± 0.5 | 15.2 ± 0.7 | 15.2 ± 0.6 | 15.4 ± 0.6 | 14.4 ± 0.4 | 14.7 ± 0.4 | 14.4 ± 0.4 | 14.5 ± 0.5 |
| HCT (%) | 44.0 ± 1.8 | 44.4 ± 2.1 | 44.4 ± 1.9 | 44.5 ± 1.8 | 41.2 ± 1.1 | 41.4 ± 1.0 | 40.7 ± 1.1 | 41.7 ± 1.5 |
| MCV (fL) | 50.8 ± 1.5 | 50.9 ± 2.0 | 51.4 ± 1.8 | 51.8 ± 1.8 | 52.9 ± 1.1 | 51.8 ± 1.2 | 53.6 ± 1.2 | 53.6 ± 1.8 |
| MCH (pg) | 17.5 ± 0.5 | 17.4 ± 0.7 | 17.6 ± 0.6 | 17.9 ± 0.6 | 18.5 ± 0.4 | 18.4 ± 0.5 | 18.9 ± 0.3 | 18.6 ± 0.5 |
| MCHC (g/dL) | 34.4 ± 0.6 | 34.1 ± 0.2 | 34.2 ± 0.3 | 34.6 ± 0.3 | 35.0 ± 0.4 | 35.5 ± 0.4* | 35.3 ± 0.5 | 34.7 ± 0.4 |
| RDW (%) | 13.0 ± 0.3 | 12.9 ± 0.4 | 12.8 ± 0.5 | 12.6 ± 0.7 | 11.8 ± 0.5 | 11.8 ± 0.3 | 11.8 ± 0.5 | 11.7 ± 0.2 |
| RETIC (109/L) | 161.8 ± 25.3 | 150.7 ± 18.7 | 169.9 ± 27.3 | 150.8 ± 26.7 | 157.0 ± 32.7 | 123.7 ± 21.6* | 149.0 ± 33.1 | 148.3 ± 24.0 |
| PLT (104/μL) | 106.5 ± 10.6 | 100.9 ± 11.4 | 112.6 ± 12.7 | 103.9 ± 12.1 | 117.4 ± 18.8 | 113.5 ± 15.9 | 112.5 ± 12.5 | 117.4 ± 13.5 |
| WBC (102/μL) | 91.5 ± 21.3 | 72.9 ± 13.3 | 78.7 ± 23.0 | 78.0 ± 15.3 | 55.3 ± 18.2 | 52.3 ± 13.3 | 50.4 ± 18.7 | 46.8 ± 12.9 |
| LYMP (102/μL) | 71.9 ± 18.7 | 58.3 ± 12.7 | 62.0 ± 20.3 | 60.3 ± 11.9 | 44.4 ± 15.5 | 40.4 ± 12.9 | 39.1 ± 14.6 | 37.0 ± 10.4 |
| NEUT (102/μL) | 15.1 ± 5.4 | 11.6 ± 3.0 | 13.3 ± 5.3 | 13.9 ± 3.5 | 8.4 ± 3.2 | 9.5 ± 4.2 | 8.8 ± 6.2 | 7.9 ± 3.1 |
| EOS (102/μL) | 1.3 ± 0.4 | 1.0 ± 0.2 | 1.0 ± 0.3 | 1.1 ± 0.4 | 0.8 ± 0.3 | 0.7 ± 0.2 | 0.8 ± 0.4 | 0.7 ± 0.3 |
| BASO (102/μL) | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.1 |
| MONO (102/μL) | 2.2 ± 0.7 | 1.3 ± 0.2* | 1.7 ± 0.5 | 1.8 ± 1.0 | 1.2 ± 0.7 | 1.2 ± 0.5 | 1.2 ± 0.6 | 0.9 ± 0.4 |
| LUC (102/μL) | 0.9 ± 0.6 | 0.5 ± 0.2 | 0.5 ± 0.4 | 0.8 ± 0.4 | 0.4 ± 0.3 | 0.4 ± 0.2 | 0.5 ± 0.4 | 0.3 ± 0.1 |
| PT (sec) | 13.5 ± 1.0 | 13.7 ± 0.7 | 13.4 ± 1.3 | 13.9 ± 1.0 | 12.5 ± 0.6 | 13.1 ± 0.6 | 12.8 ± 1.0 | 13.2 ± 1.2 |
| APTT (sec) | 16.9 ± 1.9 | 16.2 ± 2.0 | 15.4 ± 1.9 | 16.9 ± 1.9 | 14.1 ± 2.0 | 15.4 ± 1.8 | 14.2 ± 1.8 | 15.2 ± 1.6 |
| Fbg (mg/dL) | 290 ± 30 | 295 ± 24 | 300 ± 20 | 289 ± 37 | 221 ± 24 | 206 ± 38 | 183 ± 10** | 180 ± 16** |
Values are means ± S.D. Significantly different from the control using Dunnett’s test (two-tailed) or Steel’s test (two-tailed): * p ≤ 0.05, ** p ≤ 0.01.
RBC, red blood cell count; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW, red blood cell distribution width; RETIC, reticulocyte count; PLT, platelet count; WBC, white blood cell count; LYM, lymphocyte count; NEUT, neutrophil count; EOS, eosinophil count; BASO, basophil count; MONO, monocyte count; LUC, large unstained cell count; PT, prothrombin time; APTT, activated partial thromboplastin time; Fbg, fibrinogen.