Table 4.

. Organ Weights Relative to Brain Weight.

		Body weight and Organ weight relative to brain weight (%)
Group		Body	Liver	Kidneys	Heart	Thymus	Spleen	Testes	Epididy-	Seminal	Pituitary	Adrenal	Thyroid
(mg/kg bw/day)		weight							mides	vesiclesa		glands
Male
0 (Control)	Mean	18975.6	455.67	97.78	47.01	17.86	31.55	164.10	70.69	104.36	0.36	3.23	0.78
(n = 10b)	SD	675.12	32.74	6.11	3.29	4.23	3.42	10.37	7.83	11.06	0.06	0.46	0.14
500	Mean	19776.2	486.45	107.30	48.82	18.10	32.15	166.85	74.66	111.27	0.35	3.12	0.84
(n = 10)	SD	1451.96	47.97	7.90	2.72	3.79	2.34	6.64	5.06	14.70	0.04	0.49	0.10
	SS			*
1000	Mean	20040.8	513.91	110.33	50.59	18.49	32.57	171.80	77.87	111.86	0.39	3.22	0.84
(n = 10)	SD	1345.49	57.95	13.46	4.05	4.21	5.53	11.59	6.87	16.06	0.06	0.42	0.13
	SS		*	**					*
2000	Mean	20062.1	500.42	112.79	49.88	13.32	31.67	166.94	71.08	111.20	0.44	3.74	0.85
(n = 10)	SD	2257.41	65.46	8.81	5.30	2.93	4.36	19.76	6.75	14.80	0.07	0.35	0.09
	SS			**		*					**	*
Test for Significance		NS	DN	DN	NS	DN	NS	NS	DN	NS	DN	DN	NS
Historical Control Range		16500.0–24796.4	375.45–660.63	88.64–144.34	42.73–61.99	11.31–26.29	22.47–41.15	146.64–196.02	55.16–85.65	65.47–154.76	NE	1.95–4.27	NE
Female								Ovaries	Uterus
0 (Control)	Mean	12016.9	364.96	74.50	36.91	15.89	24.36	4.26	37.61		0.49	3.99	1.09
(n = 10)	SD	1010.67	62.28	3.97	3.25	4.30	3.81	1.23	6.63		0.08	0.52	0.15
500	Mean	12023.8	345.72	76.35	36.58	15.30	24.98	5.20	38.60		0.54	4.21	1.17
(n = 10)	SD	1203.76	42.81	9.88	3.33	3.26	4.08	1.21	7.10		0.09	0.83	0.32
1000	Mean	11941.0	356.81	75.48	35.46	15.58	25.90	5.77	37.56		0.48	4.26	1.01
(n = 10)	SD	743.17	40.51	5.75	2.26	2.06	3.43	1.55	6.61		0.06	0.46	0.15
	SS							*
2000	Mean	12180.9	333.80	75.38	34.68	14.84	23.80	5.39	38.19		0.56	4.50	1.04
(n = 10)	SD	1219.24	38.34	6.89	3.28	2.46	2.81	1.01	8.40		0.07	0.58	0.12
Test for Significance		NS	NS	NS	NS	NS	NS	DN	NS		NS	NS	NS
Historical Control Range		10000.0–13686.6	263.82–408.74	66.67–125.81	30.29–44.09	8.96–21.86	17.11–28.87	3.49–7.00	20.85–51.63		NE	2.99–5.56	NE

Abbreviations: DN, Duncan's multiple range test; NE, laboratory historical control data not yet established—new parameter in accordance with OECD 408 (25 June 2018); NS, Not Significant; SD, standard deviation; SS, statistically significant compared to control.

Remarks: Paired organs were weighed together.

^aSeminal vesicle coagulating gland and prostate (as a whole).

^bn = 9 for adrenal glands of control group males (adrenal glands one control male animal were not weighted due to loss at necropsy).

^*p < 0.05.

^**p < 0.01.