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. 2020 Sep 14;7:1242–1254. doi: 10.1016/j.toxrep.2020.08.030

Table 5.

Summary of Histopathology Findings.

Dose group (mg/kg bw/day) Control (0) 500 1000 2000
Organs Observations (n = 10) N/A N/A (n = 10)
Male
Animals with no microscopic findings 3/10 N/A N/A 3/10
Kidneys: Pelvic dilatation, slight, one or two sides 1/10 5/5 / 1/10
Liver: Cetrilobular vacuolation, mimimal to moderate 61–3/10 / / 71–3/10
Lungs: Alveolar emphysema, minimal 21/10 / / 11/10
Hyperplasia of BALT, minimal to mild 21–2/10 / / 12/10
Stomach: Ulceration, moderate 0/10 13/1 / 0/10



Female
Animals with no microscopic findings 7/10 N/A N/A 3/10
Kidneys: Pelvic dilatation, slight, both sides 0/10 2/2 / 1/10
Lungs: Alveolar emphysema, minimal 11/10 / / 0/10
Hyperplasia of BALT, minimal 11/10 / / 0/10
Mesenteric lymph nodes: Hemorrhage, mild 0/10 / / 12/10
Ovaries: Lack of corpora lutea 1/10 / / 0/10
Uterus: Dilatation 2/10 / / 6/10
Adenoma 0/10 / / 1/10
Abdominal cavity: Lipoma 1/1 / / /

Abbreviations: /, not examined; BALT, bronchus associated lymphoid tissue; N/A, not applicable (only gross lesions were examined).

Data represent incidence of the observation (number of animals with observation per number of animals examined).

Organs without lesions in 10/10 control and high-dose animals or without gross lesions at necropsy not shown.

Superscripts represent grades of lesions: 1 = minimal, 2 = mild, 3 = moderate, 4 = severe.