Table 5.
Summary of Histopathology Findings.
| Dose group (mg/kg bw/day) | Control (0) | 500 | 1000 | 2000 | |
|---|---|---|---|---|---|
| Organs | Observations | (n = 10) | N/A | N/A | (n = 10) |
| Male | |||||
| Animals with no microscopic findings | 3/10 | N/A | N/A | 3/10 | |
| Kidneys: | Pelvic dilatation, slight, one or two sides | 1/10 | 5/5 | / | 1/10 |
| Liver: | Cetrilobular vacuolation, mimimal to moderate | 61–3/10 | / | / | 71–3/10 |
| Lungs: | Alveolar emphysema, minimal | 21/10 | / | / | 11/10 |
| Hyperplasia of BALT, minimal to mild | 21–2/10 | / | / | 12/10 | |
| Stomach: | Ulceration, moderate | 0/10 | 13/1 | / | 0/10 |
| Female | |||||
| Animals with no microscopic findings | 7/10 | N/A | N/A | 3/10 | |
| Kidneys: | Pelvic dilatation, slight, both sides | 0/10 | 2/2 | / | 1/10 |
| Lungs: | Alveolar emphysema, minimal | 11/10 | / | / | 0/10 |
| Hyperplasia of BALT, minimal | 11/10 | / | / | 0/10 | |
| Mesenteric lymph nodes: | Hemorrhage, mild | 0/10 | / | / | 12/10 |
| Ovaries: | Lack of corpora lutea | 1/10 | / | / | 0/10 |
| Uterus: | Dilatation | 2/10 | / | / | 6/10 |
| Adenoma | 0/10 | / | / | 1/10 | |
| Abdominal cavity: | Lipoma | 1/1 | / | / | / |
Abbreviations: /, not examined; BALT, bronchus associated lymphoid tissue; N/A, not applicable (only gross lesions were examined).
Data represent incidence of the observation (number of animals with observation per number of animals examined).
Organs without lesions in 10/10 control and high-dose animals or without gross lesions at necropsy not shown.
Superscripts represent grades of lesions: 1 = minimal, 2 = mild, 3 = moderate, 4 = severe.