Table 1.

Effects of apolipoproteins in BC development

Apolipoproteins	Location	Effects and significance
ApoD	Serum	ApoD expression is positively associated with BC risk
	Cancer tissue	ApoD inhibits tumor cells proliferation ApoD expression is inversely associated with BC malignant degree and is considered as a prognostic factor
	Adjacent stroma	ApoD promotes stromal cells senescence and then advanced tumor invasion
ApoE	Serum	ApoE expression shows a positive association with the degree of BC malignancy
	Cancer tissue	ApoE may inhibit the formation of angiogenesis and the proliferation of BC cells
ApoA-I	Serum	ApoA-I expression is inversely associated with BC risk and tumor size Overexpression of apoA-I may not benefit BC patients ApoA-I is involved in BC metastasis
	Cancer tissue	Administration of apoA-I mimetic peptide (D-4F) in mammary tissues prevents the proliferation of BC MCF-7 cells
ApoJ	Cancer tissue	ApoJ inhibits the apoptosis of cancer cells, and its expression is positively correlated with ER- or PR- BC, especially TNBC Knocking down or silencing apoJ inhibits tumor growth and metastasis
ApoB	Serum	ApoB functions as a risk factor for BC metastasis; ApoB may promote ER + MCF-7 cell multiplication via 27-HC
ApoC-I	Serum	ApoC-I has low expression in BC patients ApoC-I distinguishes TNBC from non-TNBC and is valuable to detect and prognosticate TNBC development ApoC-I peptides suppress the proliferation of MCF-7 and MDA-MB-231 cells
ApoM	Cancer tissue	ApoM may inhibit the proliferation of breast carcinoma cells