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. 2020 Feb 22;36(5):417–435. doi: 10.1007/s10565-020-09516-6

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© The Author(s) 2020

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Fig. 6 — General overview of the RNA-seq assessment for T47D cells exposed to E2 or DES (10 nM) compared with the solvent control (DMSO) presented in (a) a heatmap of differentially expressed genes significantly different (FDR < 0.05) in at least 1 of the treatments (red, high expressed genes; green, low expressed genes); and (b) Principal Coordinates Analysis plot for E2, DES and the solvent control (DMSO) also including—to facilitate comparison—the data for 6 other treatment groups analyzed in the same experiment, including all-trans retinoic acid (AtRA) and the synthetic retinoids 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl] benzoic acid (Am80), 5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-3-thiophenecarboxylic-acid (CD2314) and 3-fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl) acetyl]amino]-benzoic acid (BMS961)