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. 2020 Sep 21;11:4765. doi: 10.1038/s41467-020-18565-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The plasma membrane of adipocytes is enriched with caveolaes. In a caveolae, CD36 is in the palmitoylated form and its FA binding cavity is on the outer layer, whereas CAV1 is on the inner layer. When FAs bind to CD36, a SRC kinase LYN gets activated, and it phosphorylates DHHC5 at Tyr91 and inactivates DHHC5, resulting in the subsequent depalmitoylation of CD36 by the depalmitoylase APT1. The depalmitoylated CD36 then recruits SYK to phosphorylate VAV and JNK, thereby initiating CD36-mediated caveolar endocytosis. The endocytosed vesicles deliver FAs to lipid droplets for storage. After that, CD36 gets re-palmitoylated and recycled to the plasma membrane for another round of delivery.