Table 2.
Minimal prevalence of PIDs in Italy and comparison with other countries. Minimal prevalence (per 105 inhabitants) of PIDs in Italy calculated on alive patients based on the latest IUIS classification (2019) and comparison with previously published data from other national PID registries. Numbers in parentheses represent total number of registered patients (bold) and total number of alive patients (italic)
| Italy (3352; 3103) | France [10] (3083; 2682) | Morocco[11] (421; 304) | Iceland [13] (66; 62) | Switzerland [14] (348; 338) | Tunisia [15] (710; 465) | The United Kingdom [17] (4758; 4297) | Kuwait [19] (314; 233) | ||
|---|---|---|---|---|---|---|---|---|---|
| I | Immunodeficiency affecting cellular and humoral immunity | 0.40 | 0.21 | 0.12 | / | / | 0.82 | 0.50 | 1.23 |
| II | Combined immunodeficiency with associated or syndromic features | 1.17 | 0.51 | 0.26 | 2.80 | 0.35 | 0.26 | 0.49 | 1.25 |
| III | Predominantly antibody deficiency | 3.28 | 2.09 | 0.22 | 7.50 | 2.65 | 1.12 | 3.92 | 1.18 |
| IV | Disease of immune dysregulation | 0.04 | / | 0.01 | / | 0.10 | 0.19 | 0.14 | 0.61 |
| V | Congenital defects of phagocyte number or function | 0.24 | 0.84 | 0.19 | 1.90 | 0.36 | 1.13 | 0.27 | 0.33 |
| VI | Defects of intrinsic and innate immunity | / | / | 0.03 | / | 0.09 | / | 0.06 | / |
| VII | Autoinflammatory disorders | / | / | 0.03 | / | 0.15 | / | 0.04 | 0.02 |
| VIII | Complement deficiency | / | 0.02 | 0.04 | 5.70 | 0.19 | 0.02 | 0.85 | 0.48 |
| IX | Bone marrow failure | 0.02 | / | / | / | / | / | / | / |