Table 4.

Classification of the main cytotoxic agents [23, 44]

Vesicant	Irritant	Non-vesicant*
DNA-binding  Amsacrine  Carmustine  Dacarbazine  Dactinomycin  Daunorubicin  Doxorubicin  Epirubicin  Idarubicin  Mechlorethamine  Nitrogen mustard  Mitomycin  Streptozotocin  Treosulfan	Bendamustine Carboplatin Cisplatin Etoposide Fluorouracil Ifosfamide Irinotecan Liposomal daunorubicin Liposomal doxorubicin Melphalan Methotrexate Mitoxantrone Oxaliplatin Temsirolimus Teniposide Topotecan Trastuzumab emtansine Aflibercept	Arsenic trioxide Asparaginase Bleomycin Bortezomib Cladribine Cyclophosphamide Cytarabine Eribulin Fludarabine Gemcitabine Monoclonal antibodies Paclitaxel albumin Pemetrexed Pentostatin Raltitrexed Thiotepa
Non-DNA-binding  Cabazitaxel  Docetaxel  Paclitaxel  Trabectedin  Vinblastine  Vincristine  Vindesine  Vinflunine  Vinorelbine